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The regulation of ferroptosis is closely related to the normal physiological process of cells, and it involves iron metabolism, lipid metabolism, and the balance between oxygen-free radical reaction and lipid peroxidation

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Results: In the DIO mouse model, where ALG-055009 was administered QD or BID for 28 days, dose-dependent increases in selective THR-induced liver gene expression were observed and were associated with reductions in serum total and LDL-C