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This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

J.KeleJ.SousaK.RawalN.et al

Splitting a larger daily dose into two servings for instance, 300 mg in the morning and 300 mg in the afternoon may improve tolerability and maintain more consistent blood levels throughout the day