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SIGNALING Emilie Crouchet 1 Mayssa DACHRAOUI 2 Frank Jhling 2 Natascha Roehlen 2 Marine Oudot 2 Sarah Durand 2 Clara Ponsolles 2 Clo Gadenne 2 Laura Meiss-Heydmann 2 Julien Moehlin 2 Romain Martin 2 Nicolas Brignon 2 Fabio Del Zompo 2 Yuji Teraoka 3 Hiroshi Aikata 3 Hiromi Abe-Chayama 4 Kazuaki Chayama 4 Antonio Saviano 5 Danijela Heide 6 Emanuele Felli 7 Patrick Pessaux 7 Mathias Heikenwlder 6 Pierre Chambon 8 Catherine Schuster 2 Joachim Lupberger 2 Atish Mukherji 2 Thomas Baumert 2 , 1 University of Strasbourg, Inserm UMR_S1110 (ITM), 2 University of Strasbourg, Inserm U1110, 3 Hiroshima University, Japan, 4 Hiroshima Institute of Life Sciences, 5 Strasbourg University Hospitals, France, 6 DKFZ, Heidelberg, Germany, 7 Strasbourg University Hospitals, IHU, 8 IGBMC, Inserm U964, Illkirsch, France Background: Liver fibrosis is the major driver for hepatocellular carcinoma and liver disease related death