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IM administration of the undiluted 50% solution results in therapeutic plasma levels in 60 minutes, whereas IV doses will provide a therapeutic level almost immediately

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These observations of a 40% to 50% reduction in LDL-C concentrations in models of LDLR deficiency are well-aligned with the results of clinical trials of the evinacumab and zodasiran ANGPTL3 targeted therapies in patients with HoFH described above