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The majority of clinical investigations conducted thus far are characterized by limited sample sizes, abbreviated intervention periods, and diverse study designs, thereby complicating the establishment of optimal dosing regimens, timing of administration, and the effective combinations of these therapeutic modalities

The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma

Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of oxycodone and acetaminophen tablets and/or precipitate withdrawal symptoms

Nature 499 , 178183 (2013)