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Despite adequate membrane permeability, this low solubility places luteolin within a Biopharmaceutics Classification System (BCS) class IItype compound, where dissolution (not permeability) is the primary barrier to oral uptake ( 4 Luteolin in female reproductive disorders Luteolin has been investigated across a wide spectrum of female reproductive conditions, ranging from endocrine-metabolic dysfunctions to inflammatory, fibrotic, infectious, and malignant disorders