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However, it should be noted that, although HTX is rapidly absorbed and reaches peak plasma concentrations within minutes, its systemic bioavailability is limited by phase I and II metabolism in the intestine and liver [53,62,70,71], so HTX is excreted mainly in urine and has a short plasma half-life (approximately 2.5 h) and a mean lifetime of around 4 h [61]

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Iron accumulation, lipid peroxidation, transcript and protein expression levels of frataxin, mitochondrial proteins, as well as mitochondrial bioenergetics were examined