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This reduces the availability of the drug in the bloodstream

C 2010, 114, 21240-21246

doi: 10.3390/antiox10071143 29 ThongnakLPongchaidechaALungkaphinA

High concentrations of resveratrol may inhibit mitochondrial complex I, while synthetic activators like SRT2104 require high doses due to poor liver targeting, increasing oxidative stress risk in extrahepatic tissues