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There is evidence from recent studies that treatment with pimobendan of dogs not in CHF may accelerate the symptoms of MVD, including increased regurgitation of blood through the mitral valve, deterioration of the chordae tendineae, and enlargement of the left side of the heart

For instance, gallic and ellagic acids, along with fisetin, were found to decrease HAT activity in THP-1 cells, resulting in the deacetylation of the p65 subunit of NF-B and attenuation of pro-inflammatory cytokine release (105, 106)

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