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We engineered a new predictive model (POCS) adopting aPCT, age and shock.We enrolled 1063 subjects: 450 reached the composite outcome of death or ICU transfer

Myricetin has been reported to increase lamellar body secretion and support the structural integrity of the epidermal lipid matrix in AD mouse model (Gao et al., 2023), while apigenin has been reported to increase the expression of AQP3, HAS, and filaggrin, upregulates skin hydration and lipid synthesis, increase lamellar body density, and increase the expression of lipid-synthesizing enzymes, indicating potential roles in epidermal hydration and barrier maintenance in cell models (Hou et al., 2013

also called MTP-131) is a cell-permeable, mitochondria-targeted tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae to improve ATP output and reduce reactive oxygen species [1] [2]

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination