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The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012

24 More potent ferroptosis inhibitors may also protect due to off-target effects

C., Bowler, R

RIPK1, a key protein in complex I, plays a decisive role in TNF--mediated signaling outcomes, influencing whether the cell survives or undergoes apoptosis based on its ubiquitination status [49, 50]