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This release can occur through different mechanisms, such as nanoparticle dissolutionan instability that arises under specific pH conditions, typically at lower pH, leading to matrix dissolutionand polymer swelling, a process in which nanoparticles swell at certain pH conditions, both ultimately resulting in drug release (Karimi et al., 2016)

Five L of samples were injected into a C18 Kinetex column, 100 2.1 mm (i.d), 100A pore size, 2.6 M particle size (Phenomenex, Torrance, California, United States) with 0.1% formic acid (as phase A) and 0.1% formic acid in acetonitrile (B)

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Disruption of cholinergic neurotransmission exacerbates Abeta-related cognitive impairment in preclinical Alzheimers disease