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Description

10.1021/jm800993r J

In reference to a protein, a "substitution variant" is one in which at least one amino acid residue in the native or reference sequence is removed and a different amino acid is inserted at the same position

Although, some small molecule prodrug systems have also been reported recently, such as the PDT-activatable prodrug system with a singlet oxygen-sensitive linker (such as amino acid ester linkers) developed recently [24]

It is possible that the processing of vitamin C causes it to become unstable, which may explain why there is evidence that co-supplementation is not more advantageous