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For all experiments, differences of datasets were considered statistically significant when P values were lower than 0.05, if not otherwise specified

Epitalons circadian-regulatory action and NAD+s mitochondrial bioenergetic support are considered complementary mechanisms rather than overlapping ones, but combination should follow a clinical review of current medications and hepatic/renal clearance considerations

Under normal physiological conditions, pericytes exhibit low turnover rates and maintain microvasculature stability over long periods of time

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