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CD4 + T-cells were stimulated and differentiated into Th1 cells following infection with SARS-CoV-2, secreting plasma-pro-inflammatory cytokines including IL-6, IFN-, and granulocytemacrophage-colony-stimulating factor (GM-CSF) (Huang et al., 2020)

We further estimate that the annual time burden across all 68 facilities would be 272 hours (4 hours 68 facilities)

doi: 10.1038/s41598-021-84569-z 4 GuoQYangCGaoF

Moreover, the RAPID-OLE study demonstrated that the lung density lost during the two years of placebo treatment is not recovered with the introduction of A1PI, thus highlighting the importance of early therapeutic intervention with a highly purified A1PI product (12, 82)