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variant is meant substitutions or alterations in the amino acid sequences of the apolipoprotein, which substitutions or alterations, e.g., additions and deletions of amino acid residues, do not abolish the activity of native apolipoprotein, including lipid binding properties

doi: 10.1159/000484955 13 ArbouzovaN

Mice and rats have a third functional de novo methyltransferase enzyme named DNMT3C, which evolved as a paralog of Dnmt3b by tandem duplication in the common ancestral of Muroidea rodents

Furthermore, hyperhomocysteinemia triggers the activation of NF-B, causing releasing of pro-inflammatory cytokines (Ferlazzo et al