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A diagnosis is confirmed when an individual has at least two of the following: a family history of Nf1 a glioma, or tumor, on the optic nerve, usually without symptoms lesions in the bone at least six caf-au-lait spots measuring more than 5 millimeters across in children or 15 millimeters in adolescents and adults at least two Lisch nodules, or small brown spots in the iris freckling in the armpits, under the breast, or in the groin area two or more neurofibromas, or one plexiform Plexiforms affect around 25 percent of people with Nf1

As for other members of the FNR superfamily, a transient displacement of a C-terminal aromatic residue is necessary to perform hydride transfer 24,25

doi: 10.1182/blood.V87.11.4887.bloodjournal87114887 156 DaviesJKYukDNadlerLMGuinanEC

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