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For example, palmitic acid, cholesterol crystals, and lipopolysaccharide can stimulate glycolysis and lipogenesis in macrophages, while impairing the tricarboxylic acid cycle and oxidative phosphorylation ( + T cells, hepatic lipid accumulation impairs both glycolysis and fatty acid oxidation, reducing their cytotoxic activity ( 3 The role of innate immunity in MASH 3.1 Kupffer cell activation and monocyte recruitment Kupffer cells are the predominant hepatic macrophage population in the healthy liver and are strategically located within sinusoids to facilitate interactions with hepatocytes, hepatic stellate cells, and endothelial cells

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Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Roth JA, Swisher SG , Walsh GL, Vaporciyan AA, Mehran RJ, Antonoff MB