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Name: acetyl-l-carnitine nct clinical trials als The Scientific and Therapeutic Rationale for Off‐Label Treatments in Amyotrophic Lateral Sclerosis - Bedlack - 2025 - Annals of Neurology Acetyl L-Carnitine
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The nanomodulators could trigger an abrupt surge in mitochondrial Ca 2+ ions and rapidly cause mitochondrial Ca 2+ overload, contributing to ROS increasement, cytochrome C secretion, caspase-3 protein activation, GSDME cleavage, and eventually the tumor cells pyroptosis