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Green et al., The vicinal lipoate thiols on the E 2 subunit of Odh can be subjected to a range of oxidative modifications

Accordingly, the present expert panel suggests that DPN should be considered in a patient with prediabetes or diabetes who presents with neuropathic symptoms (involve both sides symmetrically) and/or signs of neuropathy in the presence of DPN risk factors (i.e., advancing age, obesity, hypertension, dyslipidemia, poor glycemic control), with careful consideration of laboratory testing to rule out other causes of distal symmetric peripheral neuropathy and referral for a detailed neurological work-up for a confirmative test of either small or large nerve fiber dysfunction only in atypical cases

Neurosurg Rev (2011) 34(3):25363

In particular, cellular detoxification by ABCC1 and ABCC2 is mediated through the efflux of metal ions such as mercury(Granitzer et al