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Of these articles, 155 were selected, summarized, and critically discussed to provide a comprehensive review

Organic acidaemias, including methylmalonic acidaemia, propionic acidaemia, isovaleric acidaemia and multiple carboxylase deficiency occur in ~1 in 21,000 births and typically lead to mild to moderate hyperammonaemia due to competitive inhibition of NAGS 5,6,7,8,9