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Administration of a GSH inhibitor into nucleus accumbens impairs PR test performance To assess whether decreasing local accumbal GSH levels alters motivated performance, rats were injected with either BSO (an inhibitor of gamma-glutamylcysteine synthetase-the rate-limiting enzyme for GSH synthesis) at 7 g/l or DMSO (the diluent of BSO) intra-NuAc (1 l per hemisphere) (Figure 4a and 4b)