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Ann Intern Med 139:642648

Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells

Dube S, Hulke SM, Wakode SL, et al

this is an important caveat for researchers designing receptor-binding studies, as it distinguishes this compound from peptides with a well-defined single-receptor mechanism