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This discrepancy highlights a key consideration for translational applications: while voluntary exercise naturally boosts irisin and may offer neuroprotective benefits, patients with neurodegenerative diseases such as Parkinsons often experience mobility limitations that restrict sustained physical activity 35

Moreover, myricetin induced apoptosis of endometriosis patient-derived cells (VK2/E6E7 and End1/E6E7) by mediating ROS, calcium ion accumulation, and causing changes in mitochondrial membrane potential (MMP)

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