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Nebido takes a significant amount of time to reach stable levels due to its relatively long half-life, but at a dose of 125mg every week, we do ultimately reach stable levels with relatively small fluctuations between the peak and trough for daily release as shown below: Figure 15 Approximate average daily release of Testosterone at 125mg of Nebido every week If this methodology was to be adopted by the NHS or within private practice, a loading dose regime could improve the time taken to achieve stability