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In summary, our results demonstrated that TG2 in cell lysates causes GST aggregate formation through crosslinking activity, which interferes with pulldown experiments and alters fused protein function

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This was coupled with a decrease in expression and secretion of IGF-1, which could explain the lack of feedback inhibitory effect on pituitary GH secretion in the fasting state

Until retatrutide receives regulatory approval, NICE guidance on weight management directs clinicians towards licensed options within established care pathways