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The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%)

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Additionally, significant associations were observed between single nucleotide variants in the NNMT gene and energy metabolism, obesity, T2D, hyperlipidemia, and hypertension (Zhu et al., 2016