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recently revealed that in response to UV stress, studies in both cultured mammalian cells and mouse models have demonstrated that SIRT7-mediated deacetylation of nucleophosmin (NPM), a nucleolar protein released from the nucleolus in response to stress stimuli, is essential for stabilizing the tumor suppressor p53, ultimately promoting cell cycle arrest and DNA repair to suppress tumorigenesis

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Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies