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This leads to a situation where white blood cells such as macrophages continue producing cytokines and, while continuing their attack on foreign microbes, release reactive oxygen species (ROS) and other chemicals that harm normal tissue

CMS may recalculate a rebate amount and provide the manufacturer of a Part B rebatable drug a report with a reconciled rebate amount when: (i) CMS identifies an agency error in the information specified in paragraphs (c) and (d)(1) of this section, including reporting system or coding errors, not later than 3 years from the date of receipt by a manufacturer of a reconciled rebate amount for the applicable calendar quarter