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The pathological hallmarks are the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the formation of Lewy bodies (LBs), of which a major component is the protein -synuclein (-syn)

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Liu Z, Xie Y, Xiong Y, Liu S, Qiu C, Zhu Z, et al

Simultaneously, hydrogen selenide (H 2 Se) generated from the metabolism of dietary selenium species is converted into selenophosphate (H 2 SePO 3 ) by the enzyme selenophosphate synthetase 2 (SEPHS2) which is then used as a substrate by the enzyme O-phosphoseryl-tRNA [Ser]Sec selenium transferase to incorporate selenium into phosphoseryl-tRNA [Ser]Sec to form Sec-tRNA [ser]sec