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10,11 In clinical practice, many patients express concerns about pore visibility and seek effective treatments

While few pathogens can infect the placenta and fetus in humans, maternal infection doesnt guarantee placental or fetal infection ( Additionally, the placenta is a source of autocrine, paracrine, and endocrine factors

It is crucial to inhibit both apoptotic and necrotic pathways simultaneously, given that both apoptotic and necrotic signalling pathways are simultaneously involved in the pathogenesis of diseases such as ischaemia/reperfusion injury 17,18,19,20

Therefore, we hypothesized that the excessive expression of GJs post-APAP exposure in hepsin / mice could be a key factor contributing to the increased severity of liver damage observed following APAP administration