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There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses

Similar to the protease discussed in the context of stroke, MS, and ALS, the cell-signaling analog of activate protein C, 3K3A-activated protein C, in addition to improving cerebrovascular integrity also diminished neuroinflammatory responses and slows the generation of amyloid-beta plaque buildup in AD model mice [129]