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The proximal stump of the lacerated tibial nerve was soaked into 5 l of 4% TB in saline in a custom-made silicone cup

Although thioredoxin is not itself imported into the ER (being an 11.6 kDa protein rather than a small tripeptide like glutathione), the pathway has been shown to influence ER lumenal redox potential, likely through the conveyance of reducing equivalents through an as-yet unknown ER-resident transmembrane protein (Poet et al., 2017)