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For example, bortezomib, a first-generation proteasome inhibitor that suppresses NF-B signalling and is approved for haematological malignancies, is associated with dose-limiting peripheral neuropathy, for which no approved prophylactic or therapeutic interventions currently exist [51, 52]

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This differs from the process in yeast, where sulfide must be incorporated first in homocysteine then converted in two steps to cysteine

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