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Although concomitant medication changes were not recommended throughout the study period, adjustments in antihypertensive and antidiabetic treatments were conceded in selected cases to avoid acute clinical complications during the trial

Creatine, an amino acid derivative, has no effect on cancer anorexia syndrome in patients with gastrointestinal cancers but may augment muscle strength and improve strength in CRC patients

As discussed above (in the section Role of mitochondria in synaptic transmission), Ca 2+ signaling is involved in the accumulation of mitochondria at the postsynaptic regions, where these organelles participate in neuronal Ca 2+ buffering and support of neurotransmission [93]