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Intra-hippocampal infusion of receptor agonist of ACh and Glu also reported to improve retention while infusion of antagonists impaired retention 58

IOC is a leading cause of mortality in individuals with chronic anemia-related disorders, such as -thalassemia and SCD, who undergo long-term transfusions, affecting approximately 2.5% of chronically transfusion-dependent SCD patients [19, 36, 41]