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In many ASD cases, the immune system makes antibodies that block the folate receptor alpha (FR) on brain cells [3]

Yet, Dmt1 deficiency had little impact on Mn levels in wild-type mice under Mn-sufficient or Mn-rich diets (Prajapati et al., 2025)

The currently available animal models, either Toxic Milk Mouse or Atp7b null mice, resulted in acute or null ATP7b protein, which cannot recapitulate the Asianspecific mutation and its corresponding phenotype