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Clinically, anti-angiogenic agents can reverse these immunosuppressive circuits by normalizing tumor vasculature (improving T-cell infiltration) and reprogramming myeloid cell populations (83)

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Damage to the BBB can impact the health and functionality of the central nervous system

For example, triphenylphosphonium cation and ischemic myocardium-targeting peptide-modified liposomes (PUE@T/I-L) were designed to target mitochondria, increasing puerarin localization in the myocardium, reducing oxidative stress, protecting myocardial cells from ischemia-reperfusion injury, and decreasing infarct size (Wang et al., 2024a)