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doi: 10.1007/s00134-003-2021-7 74 CheonSY

This compromised intestinal barrier function may lead to the translocation of noxious compounds, such as microbial metabolites (e.g., lipopolysaccharide (LPS)) and AGEs from lumen into the circulation, subsequently triggering innate danger signaling to prime host immune responses

Rssig L, Hoffmann J, Hugel B, Mallat Z, Haase A, Freyssinet JM, Tedgui A, Aicher A, Zeiher AM, Dimmeler S (2001) Vitamin C inhibits endothelial cell apoptosis in congestive heart failure