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Upon binding with specific death ligands, death receptors receive extracellular death signals and initiate apoptotic signaling by recruiting specific adaptor proteins, which subsequently activate the caspase cascade

doi: 10.1038/s41590-019-0466-2 178 LiuYWangWZhangJGaoSXuTYinY

To conceptualize the biological basis of this process, fourteen hallmarks of ageing have been proposed, including genomic instability, telomere attrition, epigenetic alterations, impaired macroautophagy, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, altered intercellular communication, chronic inflammation, stem cell exhaustion, and dysbiosis [105]