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When you have too many free radicals and not enough antioxidants to balance them out, your body experiences something called oxidative stress

Adequate dietary methionine and a sufficient supply of the nutrients required for the remethylation of homocysteine to methionine (5-methylTHF, methylcobalamin, and betaine) are required to generate sufficient SAMe

Mutations in superoxide dismutase 1 ( SOD1 ), C9orf72 (chromosome 9 open reading frame 72), and TARDBP (TAR DNA-binding protein 43) are associated with familial ALS, whereas the majority of ALS cases are sporadic [100, 101]

The increased activity of these enzymes ensures that free-radical activity is greatly diminished and that carcinogens are blocked