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Clinicians can measure urinary levels of TMA and TMAO either in steady state or after a dietary challenge and can offer genetic testing for known FMO3 variants

J Bacteriol 203(13):e0004621

That decline correlates with reduced skin repair capacity, but the correlation does not prove that topical supplementation reverses the deficit

A 2019 study published in Frontiers in Endocrinology looked at over 9,000 adults and discovered that serum B12 concentrations were lower among obese adults than non-obese adults 7