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The first hit is characterized by chronic stress-induced release of glucocorticoids and High Mobility Group Box 1 (HMGB1)

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In VRK2-KO cells, most of cells displayed ER distribution of SLC7A11 regardless of monensin addition or removal, suggesting that VRK2 did not have an influence on Golgi-to-PM trafficking of SLC7A11 (Fig