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The human brain is especially vulnerable to oxidative stress because it accounts for only 2% of body mass but consumes 20% of oxygen 14

10.1016/j.mito.2013.01.008 Mitochondrion 183 VenkatakrishnanP.NakayasuE

As a result, surgical damage to the hypothalamus is a key contributor to the risk of postoperative weight gain[99], which, perhaps surprisingly, does not seem to be exacerbated by radiation-based adjuvant treatment [31]