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The alignment parameters were imported to FREALIGN for pseudohelical refinement (twist 27.64, rise 9.695 ) and an established seam detection protocol 73

MartinezPJMathewsCActorJKHwangSABrownELDe SantiagoHKet al

74 Moreover, UC patients also have an increased prevalence of chronic diseases, such as chronic kidney disease, 75 atherosclerosis, 76 and mental illness

Notably, the results of bioinformatics analyses indicate that GPX4 and ACSL4 are positively and negatively correlated with the sensitivity of sorafenib in RCC, respectively (Fig