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Odevixibat, a small molecule that inhibits ileal resorption of BAs belonging to the class of ileal BAs transporter (IBAT) inhibitors, was the first drug approved for the treatment of PFIC patients 6 months old due to its efficacy on both pruritus and reduction of serum BAs as well as its good tolerability in 2021 [16]

The role of Lactobacillus in CAC In consideration of the relationship between IBD and Colitis-associated Colorectal cancer (CAC), as well as the anti-inflammatory effect of Lactobacillus, wonders were raised whether Lactobacillus would have the anti-tumor ability in tumorigenesis or therapeutic capability in the treatment of CAC