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10.1016/j.neulet.2014.11.013 52 FineJ

In studies involving cortical injury and lipopolysaccharide (LPS)-induced neuroinflammation, CR has been shown to significantly reduce microglial activation (238)

Dipeptide linkers containing amino acids like Arg or Leu in the P2 position (e.g., Leu-Arg) are effectively processed by these enzymes (Zhang Y et al., 2023)

The hope that this therapeutic approach would not have suffered by the phenomenon of resistance was based on the fact that was targeting normal vessels rather than tumour cells prone to mutation and subject to drug induced selection