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We found that cells with iNOS knockdown had a reduced sensitivity to BSO-induced accumulation of cellular ROS level and cell death compared to cells transfected with the control siRNAs (Fig

However, if the goal is specifically treating post-acne marks, sun spots, or melasma patches defined areas of hyperpigmentation topical kojic acid is the more targeted, better-evidenced, and significantly lower-risk approach

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Advanced protocol: Some researchers use up to 2.5 to 3 mg weekly, though evidence supporting additional benefit from higher doses remains limited while side effect potential increases