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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

It then travels to the thalamuss tertiary neurons, which in turn send pain signals to the frontal lobe, cingulate gyrus, and parietal lobe (Ho et al., 2010

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Inhibition of this process takes place by blocking the enzyme in fat metabolism - ATP-Citrat-Oxalacetat-Lyase