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Concurrently, it activates mTOR to enhance glycolysis and IL-2 autocrine signaling, synergizing with butyrate for robust antigen-specific T cell expansion (108)

The activation of downstream effectors, including HO-1, NQO1, and -GCS, was facilitated by the effect of H 2 O 2 exposure on oxidative molecules, which stimulated Nrf2 signaling

From a clinical perspective, functional imaging of hypoxia, redox imbalance, and acidosis is increasingly being explored as part of a precision oncology framework

Accordingly, in vivo administration of NAC attenuates the acute colitis through increased mucosal GSH levels, suggesting that GSH precursors may be of relevance in the acute relapse of IBD